Peptide Trainings

Tesamorelin

FDA-approved GHRH analog for visceral fat reduction

Tesamorelin is a synthetic version of a hormone your brain naturally produces to tell your pituitary gland to release growth hormone. It is FDA-approved for a specific condition that causes excess belly fat in HIV patients, but it is also used off-label by people who want to reduce deep abdominal fat (called visceral fat) and improve their body composition. Visceral fat is the dangerous kind that wraps around your organs — not just the kind you can pinch.

Mechanism of action

Tesamorelin tells your pituitary gland (a small gland at the base of your brain) to release growth hormone in natural pulses, the same way your body does it on its own. That growth hormone then signals your body to break down stored fat for energy, particularly the deep belly fat around your organs. It also raises IGF-1, a growth factor that supports muscle maintenance and overall body composition.

Benefits discussed in research

  • Reduces visceral (abdominal) fat significantly
  • Improves body composition
  • Increases IGF-1 levels
  • Improves cognitive function (studied)
  • Cardiovascular benefits

Research status

FDA Approved

Dosing information

For educational and research purposes only. Not medical advice.

typical
1–2 mg per day
range
1–2 mg/day
frequency
Once daily, in the morning
route
Subcutaneous injection
cycleLength
3–6 months
notes
Best taken in the morning on an empty stomach. Results are typically seen within 3 months.

Side effects and safety

  • Injection site reactions
  • Fluid retention (edema)
  • Joint pain
  • Glucose intolerance
  • Carpal tunnel syndrome (rare)

Frequently asked questions

How is tesamorelin different from HGH?

HGH is the actual hormone — injecting it directly adds growth hormone to your body from the outside. Tesamorelin tells your pituitary gland (the part of your brain that controls hormone release) to produce more of its own growth hormone. Your body releases it in natural pulses, which is safer and has fewer side effects than flooding your system with synthetic hormone all at once.

Research references

Read the Tesamorelin profile

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