CJC-1295
A long-acting GHRH analog for sustained growth hormone release
CJC-1295 is a modified version of a hormone your brain naturally uses to tell your pituitary gland to release growth hormone. The original version of this signal lasts only minutes in your body. CJC-1295 was engineered to last days by attaching to a blood protein called albumin, which acts like a slow-release carrier. The result is a steady, sustained increase in growth hormone over time, rather than a quick spike. It is almost always used together with Ipamorelin for a synergistic effect.
Mechanism of action
CJC-1295 docks onto the GHRH receptor in your pituitary gland — the same receptor your brain's natural growth hormone signal uses. This tells the pituitary to produce and release growth hormone. What makes CJC-1295 different from the natural signal is its DAC modification, which lets it attach to albumin (a blood protein) and hitch a ride through your bloodstream for days instead of minutes. This keeps growth hormone levels elevated in a sustained, natural-feeling way rather than a sharp spike.
Benefits discussed in research
- Increases growth hormone and IGF-1 levels
- Promotes lean muscle mass gain
- Reduces body fat
- Improves sleep quality and recovery
- Enhances protein synthesis
- Anti-aging effects
Research status
Phase II
Dosing information
For educational and research purposes only. Not medical advice.
- typical
- 1–2 mg per week
- range
- 1–2 mg/week
- frequency
- Once or twice per week
- route
- Subcutaneous injection
- cycleLength
- 8–12 weeks
- notes
- Almost always stacked with Ipamorelin for synergistic GH release. The combination provides a more natural, pulsatile GH release pattern.
Side effects and safety
- Water retention
- Tingling or numbness
- Fatigue
- Injection site reactions
- Potential insulin resistance at high doses
Frequently asked questions
What is the best stack with CJC-1295?
The most popular combination is CJC-1295 with Ipamorelin, and for good reason. CJC-1295 raises your baseline growth hormone level throughout the day. Ipamorelin adds a clean pulse of growth hormone on top of that. Together they produce more total GH release than either one alone, without the side effects that come from forcing a large single spike.
Research references
Read the CJC-1295 profileRelated peptides
- Ipamorelin
A selective GH secretagogue with minimal side effects
- Sermorelin
The original GHRH analog for natural growth hormone optimization
- GHRP-6
A classic growth hormone secretagogue that also significantly increases appetite
- Hexarelin
A potent GHRP with strong GH release and cardioprotective properties